Cardiovascular Cell Biology and Systems Medicine

Our group studies the cell biology of cardiovascular diseases. We utilize a human model system of induced pluripotent stem cells (iPSCs) in combination with site-specific genome editing, as well as biochemical and systems biology approaches.

Using these tools, we investigate the function of genetic variants in heart diseases, such as dilated and hypertrophic cardiomyopathy (DCM/HCM), which are leading causes of heart failure world-wide. Specifically, we are focusing on the interdependencies between mitochondrial function, metabolism and cellular homeostasis in cardiomyocytes and the cardiac vasculature.

Our goals are to recapitulate and rescue disease phenotypes in our human model of iPSC-derived cells, to understand molecular functions in cardiac health and disease, and to assess novel therapeutic directions, integrating systems medicine approaches.

Arbeitsgruppenleiterin & SFB1002-Teilprojektleiterin

Dr. rer. nat. Antje Ebert


Lab members

Asset Amenov
Ph.D. student
Telefon: 0551-39-66309
E-Mail: asset.amenov(at)

Luca Avenali
Telefon: 0551-39-66309
E-Mail: luca.avenali(at)

Yuanyuan Dai
Ph.D. student
Telefon: 0551-39-66309
E-Mail: yuanyuan.dai(at)

Nadezda Ignatyeva
Ph.D. student
Telefon: 0551-39-66309
E-Mail: nadezda.ignatyeva(at)

Shrivatsan Sampathkumar
Telefon: 0551-39-66309
E-Mail: shrivatsan.sampathkumar(at)

Ruheen Wali
Telefon: 0551-39-66309
E-Mail: ruheen.wali(at)

Hang Xu
Ph.D. student
Telefon: 0551-39-66309
E-Mail: hang.xu(at)

Former lab members

Tatiana Pochechueva
E-Mail: tatiana.pochechueva1(at)

Ronald Siaden-Ortega
E-Mail: r.siadenortega(at)

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