Zelluläre Biophysik und Translationale Kardiologie
Cellular Biophysics and Translational Cardiology Section
A major focus of the Cellular Biophysics and Translational Cardiology Section are molecularly defined mechanisms and pathways, which control heart muscle function and underlie key pathophysiological changes associated with a variety of frequent and rare cardiovascular diseases. We use a broad spectrum of techniques including biophysical methods related to electrophysiology, cell biology with a focus on atrial and ventricular cardiomyocytes, molecular biology (e.g. cloning of expression plasmids and fusion proteins), high-resolution imaging (confocal and super-resolution STED microscopy), and transgenic models established by gene-editing strategies and analyzed by comprehensive phenotyping methods. Calcium-regulatory and calcium-regulated proteins are our central interest including Ryanodine Receptor (RyR) calcium release channels, Phospholamban, and Dysferlin, as well as their pathogenic mutations in humans. We also develop new classes of Multi-Targeted Drug Substances (MTDS) to mitigate dysregulated intracellular calcium signaling for example in the context of different forms heart failure and arrhythmia.
We are a founding member of the Excellence Cluster “Multi-scale Bioimaging – from Molecular Machines to Networks of Excitable Cells” (MBExC). Our campus-wide activities include, but are not limited to, the understanding of voltage-dependent calcium channel regulation through ion channel clustering, the role of different Ferlin proteins for vesicle fusion and membrane repair, and the development and application of innovative imaging techniques through interdisciplinary collaborations in academia and industry. We develop and apply a variety of advanced mass spectrometry workflows, for instance affinity proteomics and proximity proteomics, in close collaboration with the Service Unit Proteomics. The biomedical spectrum of available models includes human stem cells and bioengineered tissues, cardiac and neuronal tissues, and patient samples. Through the Hertha Sponer College and the Heart and Brain graduate school GRK 2428 we promote advanced support structures for M.Sc./Ph.D and cand. med. doctoral tracks, and scientific-to-biomedical exchange throughout academic career tracks.
For more information, please contact:
Prof. Dr. med. Stephan E. Lehnart, PD Dr. med. Sören Brandenburg, or Christiane Schulz
Our research group is located in the Heart Research Center Göttingen.
Vacancies
Please feel free to send in a speculative application at any time.
contact information
- e-mail address: slehnart(at)med.uni-goettingen.de
secretariat
- telephone: +49 551 3963631
- fax: +49 551 3963724
- e-mail address: cschulz(at)med.uni-goettingen.de
Mitarbeiter*innen
contact information
- telephone: +49 551 3963631
- fax: +49 551 3963724
- e-mail address: cschulz(at)med.uni-goettingen.de
Raum: 5 A2 32
contact information
- telephone: +49 551 3963643
- e-mail address: soeren.brandenburg(at)med.uni-goettingen.de
Facharzt für Innere Medizin
contact information
- telephone: +49 551 3963637
- e-mail address: brian.foo(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963640
- e-mail address: tobias.kohl(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963642
- telephone: +49 551 3963643
- e-mail address: brigitte.korff(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963637
- e-mail address: mufassra.mushtaq(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963643
- e-mail address: gabriel.riedemann(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963679
- e-mail address: tschulte(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3966315
- e-mail address: anamaria.vergellon(at)med.uni-goettingen.de
Doktorand*innen
contact information
- telephone: +49 551 3963637
- e-mail address: carolin.fleischhacker(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963637
- e-mail address: anastasiia.gorshkova(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963640
- e-mail address: jumana.jaber(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963637
- e-mail address: lorenz.liebmann(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963649
- e-mail address: marcel.rapoehn(at)stud.uni-goettingen.de
contact information
- telephone: +49 551 3963645
- e-mail address: jasper.wedemeyer(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963645
- e-mail address: justus.wegener(at)med.uni-goettingen.de
contact information
- telephone: +49 551 3963637
- e-mail address: yannik.zuehlke(at)med.uni-goettingen.de
Ehemalige Mitglieder
Dana El Chami, Ph.D.
Student
Gregory Antonios, Ph.D.
Research Scientist
Miroslav Dura, Ph.D.
Research Scientist
Sarah Gockel
MD/PhD Student
Konstantin Gusev Ph.D.
E-Mail: kgusev(at)incras.ru
Institute of Cytology of the Russian Academy of Sciences
Dr. med. Kristian Hellenkamp
Oberarzt | Ambulanz für fortgeschrittene Herzinsuffizienz
Alex Johnston
PhD Student - IRTG 1816
Aruna Kalyanasundaram
PhD Student
Dr. Daniel Kownatzki-Danger
Research Scientist
Lina Paola Baena Lozada
Medical Laboratory Technician
Jonas Peper
Ph.D. student
Nour Raad, MD. Ph.D.
Resident
Dipl.-Biol. Julia Hanni Steinbrecher
General Electric (GE) Healthcare
Dr. Jan-Hendrik Streich
Medical Advisor, Novartis Pharma GmbH
Dennis Uhlenkamp
Ph.D. student
Dr. rer. nat. Eva Wagner
Research Scientist
PD Jörg Wegener
Research Scientist
Dr. rer. nat. Silvio Weber
Research Group Leader, TU Dresden, Christian-Albrechts-Universität zu Kiel
Dr. rer. nat. Gunnar Weninger
Research Scientist
Erdem Yilmaz
Ph.D. Student
Nina Zaremba
PhD Student