Zelluläre Biophysik und Translationale Kardiologie

Research Unit for Cellular Biophysics and Translational Cardiology

A major focus of the working group of Translational Cardiology are molecular mechanisms, which control muscle function and pathophysiological changes due to disease. We use a variety of techniques including biophysics, cell biology, molecular biology, high-resolution imaging (confocal and super resolution microscopy; voltage mapping), transgenic models and comprehensive phenotyping methods. In particular, calcium binding proteins and intracellular calcium signaling are a major interest. For example cardiac ryanodine receptor (RyR2) calcium release channels, which control cardiac contraction and relaxation and modulate physiological stress adaptation during the fight-or-flight response. On the other hand, RyR2 channel dysfunction contributes to heart failure, arrhythmias, and sudden cardiac death. We develop therapeutic options for RyR2 mutation carriers with the syndrome Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), characterized by stress-induced syncope and sudden death. Because RyR2 and other calcium binding proteins can directly contribute to cardiac and other disease forms, the molecular and cellular mechanisms are investigated. A large part of our research activities is "translational" by nature and contributes to increased understanding of the molecular basis of diseases like heart failure and sudden cardiac death. Additionally, novel diagnostic and therapeutic strategies are developed and tested. Our research group is located in the Heart Research Center Göttingen.


Arbeitsgruppenleiter und SFB1002-Teilprojektleiter

Prof. Dr. med. Stephan E. Lehnart

Kontaktinformationen

Sekretariat

Mitarbeiter*innen

Christiane Schulz
Sekretariat Prof. Lehnart
Telefon: 0551 39 63631
Telefax: 0551 39 63724
E-Mail: cschulz(at)med.uni-goettingen.de
Ort:1.160

Gregory Antonios, Ph.D.
Research Scientist
Telefon: 0551 39 63640
E-Mail: gregory.antonios(at)med.uni-goettingen.de

Dr. med. Sören Brandenburg
Clinical and Research Fellow
Telefon: 0551 39 63637
E-Mail: soeren.brandenburg(at)med.uni-goettingen.de

Miroslav Dura, Ph.D.
Research Scientist
Telefon: 0551 39 63640
E-Mail: miroslav.dura(at)med.uni-goettingen.de

Dr. rer. nat. Tobias Kohl
Associated Research Scientist
Telefon: 0551 39 63640
E-Mail: tobias.kohl(at)med.uni-goettingen.de

Brigitte Korff
Medical Laboratory Technician
Telefon: 0551 39 63642/63643
E-Mail: brigitte.korff(at)med.uni-goettingen.de

Tatiana Pochechueva
Research Scientist
Telefon: 0551 39 63640
E-Mail: tatiana.pochechueva1(at)med.uni-goettingen.de

Birgit Schumann
Medical Laboratory Technician
Telefon: 0551 39 63649/63644
E-Mail: birgit.schumann(at)med.uni-goettingen.de

Dr. rer. nat. Eva Wagner
Research Scientist
Telefon: 0551 39 63640
E-Mail: eva.wagner(at)med.uni-goettingen.de

PD Dr. Jörg Wegener
Research Scientist
Telefon: 0551-39-63640
E-Mail: joerg.wegener(at)med.uni-goettingen.de

Dr. rer. nat. Gunnar Weninger
Research Scientist
Telefon: 0551 39 63637
E-Mail: gunnar.weninger(at)med.uni-goettingen.de

Doktorand*innen

Daniel Kownatzki-Danger
Ph.D. student
Telefon: 0551 39 63637
E-Mail: daniel.kownatzki(at)med.uni-goettingen.de

Jan Pawlowitz
med. Ph.D. student
Telefon: 0551 39 63637
E-Mail: jan.pawlowitz(at)stud.uni-goettingen.de
Ort: 1.166

Jonas Peper
Ph.D. student
Telefon: 0551 39 63637
E-Mail: jonas.peper(at)med.uni-goettingen.de

Hanne-Lea Schönberger
med. Ph.D. student
Telefon: 0551 39 63637
E-Mail: hanne-lea.schoenberger(at)med.uni-goettingen.de
Ort: 1.166

Dennis Uhlenkamp
Ph.D. student
Telefon: 0551 39 63637
E-Mail: dennis.uhlenkamp(at)med.uni-goettingen.de

Ehemalige Mitglieder

Sarah Gockel
MD/PhD Student

Konstantin Gusev Ph.D.
E-Mail: kgusev(at)incras.ru
Institute of Cytology of the Russian Academy of Sciences

Dr. med. Kristian Hellenkamp 
Oberarzt | Ambulanz für fortgeschrittene Herzinsuffizienz

Alex Johnston
PhD Student - IRTG 1816

Nour Raad, MD. Ph.D.
Resident

Dipl.-Biol. Julia Hanni Steinbrecher
General Electric (GE) Healthcare

Dr. Jan-Hendrik Streich
Medical Advisor, Novartis Pharma GmbH

Dr. rer. nat. Silvio Weber
Research Group Leader, TU Dresden, Christian-Albrechts-Universität zu Kiel 

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