Zelluläre Biophysik und Translationale Kardiologie
Cellular Biophysics and Translational Cardiology Section
A major focus of the working group of Translational Cardiology are molecular mechanisms, which control muscle function and pathophysiological changes due to disease. We use a variety of techniques including biophysics, cell biology, molecular biology, high-resolution imaging (confocal and super resolution microscopy; voltage mapping), transgenic models and comprehensive phenotyping methods. In particular, calcium binding proteins and intracellular calcium signaling are a major interest. For example cardiac ryanodine receptor (RyR2) calcium release channels, which control cardiac contraction and relaxation and modulate physiological stress adaptation during the fight-or-flight response.
On the other hand, RyR2 channel dysfunction contributes to heart failure, arrhythmias, and sudden cardiac death. We develop therapeutic options for RyR2 mutation carriers with the syndrome Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), characterized by stress-induced syncope and sudden death. Because RyR2 and other calcium binding proteins can directly contribute to cardiac and other disease forms, the molecular and cellular mechanisms are investigated. A large part of our research activities is "translational" by nature and contributes to increased understanding of the molecular basis of diseases like heart failure and sudden cardiac death. Additionally, novel diagnostic and therapeutic strategies are developed and tested.
Our research group is located in the Heart Research Center Göttingen.
Please feel free to send in a speculative application at any time.
Gregory Antonios, Ph.D.
Miroslav Dura, Ph.D.
Konstantin Gusev Ph.D.
Institute of Cytology of the Russian Academy of Sciences
Dr. med. Kristian Hellenkamp
Oberarzt | Ambulanz für fortgeschrittene Herzinsuffizienz
PhD Student - IRTG 1816
Dr. Daniel Kownatzki-Danger
Lina Paola Baena Lozada
Medical Laboratory Technician
Nour Raad, MD. Ph.D.
Dipl.-Biol. Julia Hanni Steinbrecher
General Electric (GE) Healthcare
Dr. Jan-Hendrik Streich
Medical Advisor, Novartis Pharma GmbH
Dr. rer. nat. Eva Wagner
Dr. rer. nat. Silvio Weber
Research Group Leader, TU Dresden, Christian-Albrechts-Universität zu Kiel
Dr. rer. nat. Gunnar Weninger